Research Timeline
Visualizing the history of Hematopoietic Stem Cell aging research from 2004 to 2028
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A Cellular and Transcriptomic Atlas of the Aged Mouse Hematopoietic System.
Ryan R White, Kun Xiong, Matthew Wakai, Allison Surian, Christina Adler, Nicole Negron, Min Ni, Tea Shavlakadze, Yu Bai, David J Glass
Single-Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys.
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.
Yuting Wang, Wenhao Zhang, Chao Zhang, Hoang Q Tran Van, Takashi Seino, Yi Zhang
The dynamics of hematopoiesis over the human lifespan.
Hojun Li, Parker Côté, Michael Kuoch, Jideofor Ezike, Katie Frenis, Anton Afanassiev, Laura Greenstreet, Mayuri Tanaka-Yano, Giuseppe Tarantino, Stephen Zhang, Jennifer Whangbo, Vincent L Butty, Enrico Moiso, Marcelo Falchetti, Kate Lu, Guinevere G Connelly, Vivian Morris, Dahai Wang, Antonia F Chen, Giada Bianchi, George Q Daley, Salil Garg, David Liu, Stella T Chou, Aviv Regev, Edroaldo Lummertz da Rocha, Geoffrey Schiebinger, R Grant Rowe
Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the life span.
Shuhei Koide, Motohiko Oshima, Takahiro Kamiya, Zhiqian Zheng, Zhaoyi Liu, Ola Rizq, Akira Nishiyama, Koichi Murakami, Yuta Yamada, Yaeko Nakajima-Takagi, Bahityar Rahmutulla, Atsushi Kaneda, Kazuaki Yokoyama, Nozomi Yusa, Seiya Imoto, Fumihito Miura, Takashi Ito, Tomohiko Tamura, Claus Nerlov, Masayuki Yamashita, Atsushi Iwama
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets.
Tsu-Yi Su, Julia Hauenstein, Ece Somuncular, Özge Dumral, Elory Leonard, Charlotte Gustafsson, Efthymios Tzortzis, Aurora Forlani, Anne-Sofie Johansson, Hong Qian, Robert Månsson, Sidinh Luc
Deciphering cell states and genealogies of human haematopoiesis.
Chen Weng, Fulong Yu, Dian Yang, Michael Poeschla, L Alexander Liggett, Matthew G Jones, Xiaojie Qiu, Lara Wahlster, Alexis Caulier, Jeffrey A Hussmann, Alexandra Schnell, Kathryn E Yost, Luke W Koblan, Jorge D Martin-Rufino, Joseph Min, Alessandro Hammond, Daniel Ssozi, Raphael Bueno, Hari Mallidi, Antonia Kreso, Javier Escabi, William M Rideout, Tyler Jacks, Sahand Hormoz, Peter van Galen, Jonathan S Weissman, Vijay G Sankaran
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity.
Jason B Ross, Lara M Myers, Joseph J Noh, Madison M Collins, Aaron B Carmody, Ronald J Messer, Erica Dhuey, Kim J Hasenkrug, Irving L Weissman
Epigenetic programming defines haematopoietic stem cell fate restriction.
Yiran Meng, Joana Carrelha, Roy Drissen, Xiying Ren, Bowen Zhang, Adriana Gambardella, Simona Valletta, Supat Thongjuea, Sten Eirik Jacobsen, Claus Nerlov
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands.
Monica Kasbekar, Carl A Mitchell, Melissa A Proven, Emmanuelle Passegué
Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution.
Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso-Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Lamo-Espinosa, Mikel San-Julian, Tamara Jiménez-Solas, Felix Lopez, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, David Gomez-Cabrero, Maria Diez-Campelo, David Valcarcel, Mikel Hernaez, Juan P Romero, Felipe Prosper
Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.
Naoki Itokawa, Motohiko Oshima, Shuhei Koide, Naoya Takayama, Wakako Kuribayashi, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Satoshi Yamazaki, Kiyoshi Yamaguchi, Yoichi Furukawa, Koji Eto, Atsushi Iwama
Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity.
Kyung Mok Kim, Anna Mura-Meszaros, Marie Tollot, Murali Shyam Krishnan, Marco Gründl, Laura Neubert, Marco Groth, Alejo Rodriguez-Fraticelli, Arthur Flohr Svendsen, Stefano Campaner, Nico Andreas, Thomas Kamradt, Steve Hoffmann, Fernando D Camargo, Florian H Heidel, Leonid V Bystrykh, Gerald de Haan, Björn von Eyss
Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
Kira Young, Elizabeth Eudy, Rebecca Bell, Matthew A Loberg, Tim Stearns, Devyani Sharma, Lars Velten, Simon Haas, Marie-Dominique Filippi, Jennifer J Trowbridge
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs.
Le Zong, Mayuri Tanaka-Yano, Bongsoo Park, Hagai Yanai, Ferda T Turhan, Deborah L Croteau, Jane Tian, Evandro F Fang, Vilhelm A Bohr, Isabel Beerman
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells.
Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schröder, Chad K Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J Sweet, Robert G Parton, Michael T Ryan, Jose M Polo, Christian M Nefzger, Susan K Nilsson
Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells.
Hérault L, Poplineau M, Mazuel A, Platet N, Remy É, Duprez E.
Understanding intrinsic hematopoietic stem cell aging.
Eva Mejia-Ramirez, Maria Carolina Florian
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.
Emmalee R Adelman, Hsuan-Ting Huang, Alejandro Roisman, André Olsson, Antonio Colaprico, Tingting Qin, R Coleman Lindsley, Rafael Bejar, Nathan Salomonis, H Leighton Grimes, Maria E Figueroa
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Maria Maryanovich, Ali H Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara, Noboru Asada, Qiaozhi Wei, Xizhe Wang, Paul Ciero, Jianing Xu, Avigdor Leftin, Paul S Frenette
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.
Mati Mann, Arnav Mehta, Carl G de Boer, Monika S Kowalczyk, Kevin Lee, Pearce Haldeman, Noga Rogel, Abigail R Knecht, Daneyal Farouq, Aviv Regev, David Baltimore
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.
Kristina Kirschner, Tamir Chandra, Vladimir Kiselev, David Flores-Santa Cruz, Iain C Macaulay, Hyun Jun Park, Juan Li, David G Kent, Rupa Kumar, Dean C Pask, Tina L Hamilton, Martin Hemberg, Wolf Reik, Anthony R Green
Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging.
Duozhuang Tang, Si Tao, Zhiyang Chen, Ievgen Oleksandrovich Koliesnik, Philip Gerald Calmes, Verena Hoerr, Bing Han, Nadja Gebert, Martin Zörnig, Bettina Löffler, Yohei Morita, Karl Lenhard Rudolph
Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.
Alexandra Rundberg Nilsson, Shamit Soneji, Sofia Adolfsson, David Bryder, Cornelis Jan Pronk
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells.
Amit Grover, Alejandra Sanjuan-Pla, Supat Thongjuea, Joana Carrelha, Alice Giustacchini, Adriana Gambardella, Iain Macaulay, Elena Mancini, Tiago C Luis, Adam Mead, Sten Eirik W Jacobsen, Claus Nerlov
Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells.
Monika S Kowalczyk, Itay Tirosh, Dirk Heckl, Tata Nageswara Rao, Atray Dixit, Brian J Haas, Rebekka K Schneider, Amy J Wagers, Benjamin L Ebert, Aviv Regev
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.
Deqiang Sun, Min Luo, Mira Jeong, Benjamin Rodriguez, Zheng Xia, Rebecca Hannah, Hui Wang, Thuc Le, Kym F Faull, Rui Chen, Hongcang Gu, Christoph Bock, Alexander Meissner, Berthold Göttgens, Gretchen J Darlington, Wei Li, Margaret A Goodell
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.
Chia-Wei Cheng, Gregor B Adams, Laura Perin, Min Wei, Xiaoying Zhou, Ben S Lam, Stefano Da Sacco, Mario Mirisola, David I Quinn, Tanya B Dorff, John J Kopchick, Valter D Longo
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Johanna Flach, Sietske T Bakker, Mary Mohrin, Pauline C Conroy, Eric M Pietras, Damien Reynaud, Silvia Alvarez, Morgan E Diolaiti, Fernando Ugarte, E Camilla Forsberg, Michelle M Le Beau, Bradley A Stohr, Juan Méndez, Ciaran G Morrison, Emmanuelle Passegué
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.
Martin Wahlestedt, Gudmundur L Norddahl, Gerd Sten, Amol Ugale, Mary-Ann Micha Frisk, Ragnar Mattsson, Tomas Deierborg, Mikael Sigvardsson, David Bryder
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.
Isabel Beerman, Christoph Bock, Brian S Garrison, Zachary D Smith, Hongcang Gu, Alexander Meissner, Derrick J Rossi
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.
Maria Carolina Florian, Karin Dörr, Anja Niebel, Deidre Daria, Hubert Schrezenmeier, Markus Rojewski, Marie-Dominique Filippi, Anja Hasenberg, Matthias Gunzer, Karin Scharffetter-Kochanek, Yi Zheng, Hartmut Geiger
Lnk deficiency partially mitigates hematopoietic stem cell aging.
Alexey Bersenev, Krasimira Rozenova, Joanna Balcerek, Jing Jiang, Chao Wu, Wei Tong
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.
Gudmundur L Norddahl, Cornelis J Pronk, Martin Wahlestedt, Gerd Sten, Jens M Nygren, Amol Ugale, Mikael Sigvardsson, David Bryder
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.
Wendy W Pang, Elizabeth A Price, Debashis Sahoo, Isabel Beerman, William J Maloney, Derrick J Rossi, Stanley L Schrier, Irving L Weissman
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.
Stuart M Chambers, Chad A Shaw, Catherine Gatza, C Joseph Fisk, Lawrence A Donehower, Margaret A Goodell
Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.
Cornelis J H Pronk, Derrick J Rossi, Robert Månsson, Joanne L Attema, Gudmundur Logi Norddahl, Charles Kwok Fai Chan, Mikael Sigvardsson, Irving L Weissman, David Bryder
Cell intrinsic alterations underlie hematopoietic stem cell aging.
Derrick J Rossi, David Bryder, Jacob M Zahn, Henrik Ahlenius, Rebecca Sonu, Amy J Wagers, Irving L Weissman